KASMEJ
Kastamonu Medical Journal

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

eISSN: 2757-9336
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Investigation of some trace element levels in multiple sclerosis
Abstract
Aims: In this study, it was aimed to investigate the relationship between multiple sclerosis (MS) and the homeostatic state of trace elements, and to reveal the relationship between Fe and Zn in MS pathology.
Methods: Total of 40 (20 patients and 20 control) subjects were participated to this study. Blood samples were taken and analysed plasma iron and zinc levels using an atomic Absorption Spectrophotometer. Kolmogrow-Smirnov Z test used to analyse statistically significance of the data. P<0.05 was accepted as significant.
Results: The plasma iron and Zn levels were found to be significantly lower in MS patients compared to control.
Conclusion: Considering the important beneficial effects of iron and zinc against neurodegenerative disease and increased oxidative stress, reduced level of these trace elements should be considered in MS treatment.

Keywords : Trace element, iron, zinc, multiple sclerosis

Download Article


1. Compston A, Coles A. Multiple sclerosis. Lancet 2008; 372:1502-17.
2. Popescu BF, Lucchinetti CF. Pathology of de- myelinating diseases. Annu Rev Pathol 2012; 7: 185-217.
3. Frischer JM, Bramow S, Dal-Bianco A, et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009; 132: 1175-89.
4. Fischer MT, Sharma R, Lim JL, et al. NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012; 135: 886-99.
5. Olsson T, Barcellos LF, Alfredsson L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol 2017; 13: 25-36.
6. Derkus B, Emregul E, Yucesan C, Cebesoy Emregul K. Myelin basic protein immunosensor for multiple sclerosis detection based upon label-free electrochemical impedance spectroscopy. Biosens Bioelectron 2013; 46: 53-60.
7. Lassmann H. Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis. Front Immunol 2019; 9: 3116.
8. Forte G, Deiana M, Pasella S, et al. Metals in plasma of nonagenarians and centenarians living in a key area of longevity. Exp Gerontol 2014; 60: 197-206.
9. Baltaci AK, Arslangil D, Mogulkoc R, Patlar S. Effect of resveratrol administration on the element metabolism in the blood and brain tissues of rats subjected to acute swimming exercise. Biol Trace Elem Res 2017; 175: 421-7.
10. Algul S, Bengu AS, Baltaci SB, Ozcelik O. Effects of morning and nocturnal soccer matches on levels of some trace elements in young trained males. Cell Mol Biol (Noisy-le-grand) 2019; 65: 32-6.
11. Mezzaroba L, Alfieri DF, Sima˜o ANC, Reiche EMV. The role of zinc, copper, manganese and iron in neurodegenerative dis- eases. Neurotoxicology 2019; 74: 230-41.
12. Popescu BF, Frischer JM, Webb SM, et al. Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions. Acta Neuropathol 2017; 134: 45-64.
13. Alizadeh A, Mehrpour O, Nikkhah K, et al. Comparison of serum concentration of Se, Pb, Mg, Cu, Zn, between MS patients and healthy controls. Electron Physician 2016; 8: 2759-64
14. Choi BY, Jang BG, Kim JH, et al. Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model. Neurobiol Dis 2013; 54: 382-91.
15. Choi BY, Jung JW, Suh SW. The emerging role of zinc in the pathogenesis of multiple sclerosis. Int J Mol Sci 2017; 18: 2070.
16. Kell DB. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genet 2009; 2: 1-79
17. Singh N, Haldar S, Tripathi AK, McElwee MK, Horback K, Beserra A. Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson&#39;s disease. Antioxid Redox Signal. 2014; 21: 471-84.
18. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 2004; 5: 863-73.
19. Filippi M, Preziosa P, Rocca MA. Multiple sclerosis. Handb Clin Neurol 2016; 135: 399-423.
20. Gelders G, Baekelandt V, Van der Perren A. Linking Neuroinflammation and Neurodegeneration in Parkinson&#39;s Disease. J Immunol Res 2018; 2018: 4784268.
21. Alimonti A, Bocca B, Pino A, Ruggieri F, Forte G, Sancesario G. Elemental profile of cerebrospinal fluid in patients with Parkinson&#39;s disease. J Trace Elem Med Biol 2007; 21: 234-41.
22. Ristori G, Brescianini S, Pino A, et al. Serum elements and oxidative status in clinically isolated syndromes: imbalance and predictivity. Neurology 2011; 76: 549-55.
23. Deli CK, Fatouros IG, Paschalis V, et al. Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. Oxid Med Cell Longev 2017; 2017: 4120421.
24. Kurtoglu E, Ugur A, Baltaci AK, Undar L. Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia. Biol Trace Elem Res 2003; 96: 117-23.
25. Matar A, Jennani S, Abdallah H, Mohsen N, Borjac J. Serum Iron and Zinc Levels in Lebanese Multiple Sclerosis Patients. Acta Neurol Taiwan 2020; 29: 5-11.
26. Pawlitzki M, Uebelh&ouml;r J, Sweeney-Reed CM, et al. Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls. Nutrients 2018; 10: 967.
27. Bredholt M, Frederiksen JL. Zinc in Multiple Sclerosis: A Systematic Review and Meta-Analysis. ASN Neuro 2016; 8: 1759091416651511.
28. Bediz CS, Baltaci AK, Mogulkoc R, Oztekin E. Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain. Tohoku J Exp Med 2006; 208: 133-40.
29. LeVine SM, Chakrabarty A. The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 2004; 1012 :252-66.
30. Armon-Omer A, Waldman C, Simaan N, Neuman H, Tamir S, Shahien R. New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients. Nutrients 2019; 11: 427.
Article available in :
Volume 1, Issue 1, 2021
Page : 1-4
https://doi.org/10.51271/KMJ-0001
Article Information
Received : 21 Mar 2021
Accepted : 30 Mar 2021
Published : 29 Ara 2022
Corresponding Author :

Sermin Algül: Van Yüzüncü Yıl University, Faculty of Medicine, Department of Physiology, Van, Turkey

[email protected]
Citation : Algül S, Kapan O, Bengü AŞ. Investigation of some trace element levels in multiple sclerosis. Kastamonu Med J. 2021;1(1):1-4.

Read: 1363
Cited: 0
Download : 511
_Footer