Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

EndNote Style
Case Report
Concurrent diagnosis of Sjogren’s syndrome and polycthemia vera: a rare co-existence
Primary Sjogren's Syndrome(pSS) is a chronic autoimmune disease and focal lymphocytic infiltration of the exocrine glands is the key pathological feature (1). Polycythemia vera(PV) is a chronic myeloproliferative disorder characterized by JAK-2 mutations and increased red blood cell mass(2,3). Autoimmune diseases and hematological malignancies can often be observed together. Patients with SS are at a higher risk of developing lymphoproliferative diseases mainly low-grade B-cell lymphomas and predominantly marginal zone lymphoma. Moreover, PV can rarely be presented with paraneoplastic events including small vessel vasculitis (2). However, PV and pSS co-existence had never been reported. We here want to present a case of concurrently diagnosed PV and pSS.

1. Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, et al. Primary Sjogren syndrome.BMJ. 2012;344:e3821. doi:10.1136/bmj.e3821
2. Abdulla MC. Paraneoplastic small vessel vasculitis and Takayasu arteritis associated with polycythemia rubra vera. Int J Rheum Dis.2020;23(7):986- 988.doi: 10.1111/1756-185X.13882
3. Ramos-Casals M, De Vita S, Tzioufas AG. Hepatitis C virus, Sjögren’s syndrome and B-cell iymphoma: linking infection, autoimmunity and cancer.Autoimmun Rev.2005;4(1):8-15. doi:10.1016/j.autrev.2004.04.004
4. Brito-Zerón P, Kostov B, Fraile G, et al. Characterization and risk estimate of cancer in patients with primary Sjögren syndrome.J Hematol Oncol. 2017;10(1):1-12. doi:10.1186/s13045-017-0464-5
Volume 3, Issue 4, 2023
Page : 216-217