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Kastamonu Medical Journal

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
The effect of general anesthesia applied during cesarean section on newborn bilirubin
Abstract
Aims: Today, delivery is often performed as normal spontaneous vaginal delivery (NSVD) and cesarean section operations. Deliveries with NSVD mostly take place in the delivery room without the need for additional anesthetic agents. General anesthesia and regional anesthesia techniques are applied in cesarean section operations. In this study; The aim of this study was to examine the effect of general anesthesia on newborn bilirubin and to compare it with the bilirubin level of babies born without general anesthesia with NSVD method.
Methods: Between March 2022 and September 2022, 152 patients over the age of 18 with term pregnancy NSVD and elective cesarean section without complications were randomly included in the study. Cases diagnosed with liver and biliary tract disease, systemic liver and biliary tract effective drug use, DCOOMBS( +) and Covid (+) clinics were excluded.
Results: Of the patients included in our study, 75 (49.3%) were given general anesthesia and 77 (50.7%) delivered with NSVD without general anesthesia. It was determined that the first hour bilirubin and the fourth hour bilirubin values were significantly higher (p <0.05) in the general anesthesia group compared to the group that did not receive general anesthesia. In the group that did not receive general anesthesia, the APGAR 5th min score was found to be significantly (p <0.05) higher than the general anesthesia group. APGAR 1 min value did not differ significantly (p > 0.05) between the anesthesia-free and general anesthesia groups. Neonatal weight, head circumference, and infant height did not differ significantly between the groups that did not receive general anesthesia and those who did not receive general anesthesia (p> 0.05).
Conclusion: Among the groups that did not receive general anesthesia and anesthesia; Bilirubin value was found to be higher among babies born by cesarean section under general anesthesia. It seems that it is more beneficial to avoid systemic effects as much as possible and to disseminate NSVD.

Keywords : General anesthesia, newborn bilirubin, cesarean section

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1. Kayhan Z. Klinik Anestezi. 2. Baskı. Logus Yayıncılık; 1997:623-638.
2. Bacon DR. The historical narrative: tales or professionalism? Anesthesiol Clin. 2008;26(1):67-74.
3. Erdem MK, &Ouml;zgen S, Coflkun F. Obstetrik Anestezi ve Analjezi. In: Kişniş&ccedil;i H, G&ouml;kşin E, eds. Temel Kadın Hastalıkları ve Doğum Bilgisi. Melisa Matbaacılık:1996:173-186.
4. Arias IM, Gartner LM, Seifter S, Furman M. Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feding and a steroid, pregnane-3(a), 20(b)-diol in maternal milk that inhibits glucuronid formation in vitro. J Clin Invest. 1964;43(11):2037-2047.
5. Rane A, Lunde PKM, Jalling B, Yaffe SJ, Sjoqvist F. Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemia infants. J Pediat. 1971;78(5):877-822.
6. Jouppilla R, Larva L, Jouppilla P, Koivisto M, Pakarinen A. Effect of segmental epidural analgesia on neonatal serum bilirubin concentration and incidence of neonatal hyperbilirubinemia. Acta Obstet Gynecol Scand. 1983:62(2):179-182.
7. Gale R, Ferguson J.E, Stevenson D.K. Effect of epidural analgesia with bupivacaine hydrochloride on neonatal bilirubin production. Obst Gynecol. 1987;70(5):692-695.
8. Chester BM. Normal fetal physiology and behavior, and adaptive responses with hypoxemia. Semin Perinat. 2008;32(4):239-242.
9. De Amici D, Delmonte P, Martinotti L, et al. Can anesthesiologic strategies for caesarian section influence newborn jaundice? a retrospective and prospective study. Biol Neonate. 2001;79(2):97-102.
10. Frink EJ. The hepatic effects of sevoflorane. Anesth Analg. 1995;81(6):46-50.
11. Watkins JB III. Exposure of rats to inhalational anesthetics alters the hepatobiliary clearance of cholephilic xenobiotics. J Pharmacol Exp Ther. 1989;250(2):421-427.
12. Scanlon JW. Neurobehavioral response and drug concentrations in newborns after maternal epidural anesthesia with Bupivacaine. Anesthesiol. 1976;45(4):400-405.
13. El-Kabbany ZA, Toaima NN, Toaima TN, El-Din MYG. Does anaesthesia in mothers during delivery affect bilirubin levels in their neonates? Korean J Pediatr. 2017;60(12):385-389. doi: 10.3345/kjp.2017.60.12.385
14. Kayacan N, Bigat Z, Yeğin A, Karslı B, akar M. A randomized prospective study on the maternal and neonatal outcome of epidural, combined spinal-epidural and general anesthesia for elective caesarean sections. T&uuml;rkiye Klinikleri J Med Sci. 2004;24:476-482.
15. Phuapradit W, Chaturachinda K, Auntlamai S. Risk faktors for neonatal hyperbilirubinemia. Med Assoc Thai. 1993;76(8):424-428.
16. Bakar FT, &Ouml;zen A, Karatepe HO, Berber M, Ercan H. Impact of early weight loss on growth of caesarean delivered babies: how long does it last? Child Care Health Dev. 2012;38(5):706-713.
Article available in :
Volume 3, Issue 4, 2023
Page : 188-191
https://doi.org/10.51271/KMJ-0124
Article Information
Received : 20 Ağu 2023
Accepted : 23 Eki 2023
Published : 17 Ara 2023
Corresponding Author :

Deniz Turan: Nisantasi Üniversitesi

[email protected]
Citation : Turan D, Karayel A. The effect of general anesthesia applied during cesarean section on newborn bilirubin. Kastamonu Med J. 2023;3(4):188-191.

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