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Kastamonu Medical Journal

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
Relationship of atherogenic index of plasma with exercise, obesity and biochemical parameters
Abstract
Aims: It is well-known that regular moderate-intensity aerobic exercise has positive effects on various health indicators, including obesity and cardiovascular diseases (CVD) and atherogenic index of plasma (AIP) is defined as a highly sensitive predictor of plasma atherogenicity and cardiovascular risk. Furthermore, it is known that physical activity has a reducing effect on AIP with its ability to decrease visceral fat and its positive impact on blood lipids. Additionally, large-scale AIP screenings are recommended for the early detection of obese individuals and effective intervention. This study aims to determine the relationship between regular exercise and cardiometabolic parameters and obesity based on current data.
Methods: The study involved a total of 126 participants aged 18-65 and it was conducted in the form of file screening, where the medical history reports of all patients were examined, and systemic physical findings were assessed. Fasting blood samples were used to determine the lipid profile. Anthropometric measurements and biochemical parameters of the participants were determined and AIP was calculated using the formula AIP=log10 (TG/HDL-C). Participants were categorized into groups based on their exercise status, BMI, and AIP risks, and the data of the study groups were evaluated statistically.
Results: Participants were divided into two groups based on exercise status, and in the exercise group, body mass index (BMI), body weight, waist circumference, AIP, and triglyceride levels were found to be lower, while high-density lipoprotein (HDL) levels were higher compared to the non-exercise group. In all participants, moderate-intensity exercise was negatively correlated with AIP, body weight, BMI, waist circumference, triglyceride, and low-density lipoprotein (LDL) levels; and positively correlated with HDL levels.
Conclusion: The relationships uncovered in this study among exercise, cardiometabolic parameters, and obesity status are expected to contribute to future research, especially in studies focusing on the impact of exercise on CVD and obesity.

Keywords : Exercise, physical activity, atherogenic index of plasma, obesity

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1. Naghavi M, Abajobir AA, Abbafati C, et al. Global, regional, and nationalage-sex specific mortality for 264 causes of death, 1980-2016: a systematicanalysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1151-1210.
2. World Health Organization. Cardiovascular diseases. Available from:https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1Accessed October 9, 2023.
3. Mann S, Beedie C, Jimene A. Differential effects of aerobic exercise,resistance training and combined exercise modalities on cholesterol andthe lipid profile: review, synthesis and recommendations. Sports Med.2014;44(2):211-221.
4. Baliarsingh S, Sharma N, Mukherjee R. Serum uric acid: marker foratherosclerosis as it is positively associated with “atherogenic index ofplasma”. Arch Physiol Biochem. 2013;119(1):27-31.
5. Holmes DT, Frohlich J, Buhr KA. The concept of precision extended tothe atherogenic index of plasma. Clin Biochem. 2008;41(7-8):631-635.
6. Bhardwaj S, Bhattacharjee J, Bhatnagar MK, Tyagi S, Delhi N. Atherogenicindex of plasma, Castelli risk index and atherogenic coefficient-newparameters in assessing cardiovascular risk. Int J Pharm Biol Sci. 2013;3(3):359-364.
7. World Health Organization. Obesity and overweight. Available from:www.who.int/mediacentre/factsheets/fs311/en/ Accessed October 12, 2023.
8. Bray GA, Kim KK, Wilding JP, World Obesity Federation. Obesity: achronic relapsing progressive disease process. A position statement of theWorld Obesity Federation. Obes Rev. 2017;18(7):715-723.
9. Aballay LR, Eynard AR, Díaz M del P, Navarro A, Muñoz SE. Overweightand obesity: a review of their relationship to metabolic syndrome,cardiovascular disease, and cancer in South America. Nutr Rev. 2013;71(3):168-179.
10. Blüher M. Metabolically healthy obesity. Endocrine Rev. 2020;(41)3. doi:10.1210/endrev/bnaa004
11. World Health Organization. Global recommendations on physicalactivity for health.. Available from: https://www.who.int/publications/i/item/9789241599979 Accessed October 9, 2023.
12. Soška V, Jarkovský J, Ravcuková B, Tichý L, Fajkusová L, Freiberger T. Thelogarithm of the triglyceride/HDL-cholesterol ratio is related to the historyof cardiovascular disease in patients with familial hypercholesterolemia.Clin Biochem. 2012;45(1-2):96-100.
13. Szostak J, Laurant P. The forgotten face of regular physical exercise: a‘natural’anti-atherogenic activity. Clin Sci. 2011;121(3):91-106.
14. Stránská Z, Matoulek M, Vilikus Z, Svacina Š, Stránský P. Aerobic exercisehas beneficial impact on atherogenic index of plasma in sedentaryoverweigh and obese women. Neuro Endocrinol Lett. 2011;32(1):102.
15. Shen S, Lu Y, Dang Y, et al. Effect of aerobic exercise on the atherogenicindex of plasma in middle-aged Chinese men with various body weights.Int J Cardiol. 2017;(1)230:1-5.
16. Edwards MK, Blaha MJ, Loprinzi PD. Influence of sedentary behavior,physical activity, and cardiorespiratory fitness on the atherogenic index ofplasma. J Clin Lipidol. 2017;11(1):119-125.
17. Ezeukwu AO, Agwubike EO, Uadia PO. Differential effects of continuousand interval exercise training on the atherogenic index of plasma in thenon-obese young male. Acta Cardiol Sin. 2015;31(4):337.
18. Riedl I, Yoshioka M, Nishida Y, et al. Regulation of skeletal muscletranscriptome in elderly men after 6 weeks of endurance training at lactatethreshold intensity. Exp Gerontol. 2010;45(11):896-903.
19. Harrison M, Moyna NM, Zderic TW, et al. Lipoprotein particledistribution and skeletal muscle lipoprotein lipase activity after acuteexercise. Lipids Health Dis. 2012;(10)11:64.
20. Zhu X, Yu L, Zhou H, et al. Atherogenic index of plasma is a novel andbetter biomarker associated with obesity: a population-based cross-sectional study in China. Lipids Health Dis. 2018;5;17(1):37.
21. Shen SW, Lu Y, Li F, et al. Atherogenic index of plasma is an effective indexfor estimating abdominal obesity. Lipids Health Dis. 2018;15;17(1):11.
22. Ross R, Neeland IJ, Yamashita S, et al. Waist circumference as a vital sign inclinical practice: a consensus statement from the IAS and ICCR WorkingGroup on Visceral Obesity. Nat Rev Endocrinol. 2020;16(3):177-189.
23. Hammond BP, Stotz PJ, Brennan AM, Lamarche B, Day AG, Ross R.Individual variability in waist circumference and body weight in responseto exercise. Med Sci Sports Exerc. 2019;51(2):315-322.
24. Armstrong A, Jungbluth Rodriguez K, Sabag A, et al. Effect of aerobicexercise on waist circumference in adults with overweight or obesity: asystematic review and meta-analysis. Obes Rev. 2022;23(8):e13446.
25. Kim KB, Kim K, Kim C, et al. Effects of exercise on the body compositionand lipid profile of ındividuals with obesity: a systematic review and meta-analysis. J Obes Metab Syndr. 2019;28(4):278-294.
26. Rahmati-Ahmadabad S, Broom DR, Ghanbari-Niaki A, Shirvani H.Effects of exercise on reverse cholesterol transport: a systemized narrativereview of animal studies. Life Sci. 2019;(1)224:139-148.
27. Muscella A, Stefàno E, Marsigliante S. The effects of exercise training onlipid metabolism and coronary heart disease. Am J Physiol Heart CircPhysiol. 2020;319(1):H76-H88.
28. Sanchis-Gomar F, Lavie CJ, Marín J, et al. Exercise effects oncardiovascular disease: from basic aspects to clinical evidence. CardiovascRes. 2022;118(10):2253-2266.
29. Zhang Y, Qi L, Xu L, et al. Effects of exercise modalities on centralhemodynamics, arterial stiffness and cardiac function in cardiovasculardisease: Systematic review and meta-analysis of randomized controlledtrials. PLoS One. 2018;13(7):e0200829.
30. Tian D, Meng J. Exercise for prevention and relief of cardiovasculardisease: prognoses, mechanisms, and approaches. Oxid Med Cell Longev.2019;(9):2019:3756750.
31. Shen S, Qi H, He X, et al. Aerobic exercise for a duration of 90 min orlonger per week may reduce the atherogenic index of plasma. Sci Rep.2018;8(1):1730.
32. Edwards MK, Loprinzi PD. Physical activity and diet on atherogenic indexof plasma among adults in the United States: mediation considerations bycentral adiposity. Eur J Clin Nutr. 2018;72(6):826-831.
33. Siahkouhian M, Ebrahimi-Torkmani B. Effect of 8-week aerobic exerciseon anthropometric indices, atherogenic index of plasma and somecardiovascular risk factors in inactive men. Sci J Rehab Med. 2021;10(3):446-457.
34. AbdulAzeez IM, Biliaminu A, Okesina B. Acute aerobic exercise as abiomodulator of atherogenic index of plasma in apparently healthyNigerian undergraduate students. DUJOPAS. 2021;7(2a):180-188.
Article available in :
Volume 4, Issue 2, 2024
Page : 33-38
https://doi.org/10.51271/KMJ-0139
Article Information
Received : 12 Oca 2024
Accepted : 02 Şub 2024
Published : 07 Haz 2024
Corresponding Author :

Şirin Çetin: Department of Biostatistics, Faculty of Medicine, Amasya University, Amasya, Turkiye

[email protected]
Citation : Olgun E, Topçu E, Çetin Ş. Relationship of atherogenic index of plasma with exercise, obesity and biochemical parameters. Kastamonu Med J. 2024;4(2):33-38.

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