KASMEJ
Kastamonu Medical Journal

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
Investigation of the frequency of wheezing and airway resistance using the interrupter technique in children born premature and over 3 years old
Abstract
Aims: The term wheezy child is a complex condition that includes different phenotypes, differences in duration and course, and a group of diseases with distinct pathophysiology. Prematurity is a risk factor for early transient wheezing. However, its restrictive effect on respiratory function tests may also predispose to persistent wheezing. This study aimed to investigate the frequency of wheezing phenotypes and their effect on airway resistance in children born prematurely and over the age of 3.
Methods: Prematurely born children over the age of 3 who were followed up in our hospital were included in our study. The effect of neonatal risk factors, especially prematurity, on persistent wheezing and increased airway resistance has been investigated. The presence of persistent wheezing and asthma in patients was investigated with the ISAAC (International Study of Asthma and Allergic Diseases in Childhood) questionnaire. To evaluate respiratory functions, airway resistance was measured with the interrupter technique.
Results: There was no significant correlation between rint values indicating airway resistance and week of gestation, birth weight, gender, mechanical ventilation, oxygen therapy, presence of BPD, and smoking exposure at home (p>0.05).
Conclusion: Although there are studies in the literature showing a relationship between recurrent preschool wheezing and prematurity. Airway resistance was successfully measured and interpreted with Rint in preschool children who could not comply with the respiratory function test. Although prematurity is expected to increase airway resistance, it is interesting that we did not detect this effect in our patients, which may be due to the limited number of extremely premature patients.

Keywords : Prematurity, persistent wheezing, airway resistance

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1. Minoo P. Transcriptional regulation of lung development: emergence of specificity. Respir Res. 2000;1:109-115. http://respiratory-research.com/content/1/2/109http://respiratory-research.com/content/1/2/109
2. Harju M, Keski-Nisula L, Georgiadis L, Räisänen S, Gissler M, Heinonen S. The burden of childhood asthma and late preterm and early term births. J Pediatr. 2014;164(2):295-299. doi:10.1016/j.jpeds.2013.09.057
3. Bridge PD, Mckenzie SA, Children9s QE. Airway Resistance Measured by the Interrupter Technique: Expiration or Inspiration, Mean or Median? Vol 17.; 2001.
4. Moss MH, Gern JE, Lemanske RF Jr. Asthma in Infancy and Childhood. In: Adkin- Son NF, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Editors. Middleton’s Allergy: Principles and Practice. 5th Ed. Philadelphia: Mosby; 2003. p. 1225-1255.
5. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson children’s respiratory study: 1980 to present. J Allergy Clin Immunol. 2003;111(4):661-675. doi:10.1067/mai.2003.162
6. Uysal P. Management of wheezy infant. Turk J Pediatr Dis. 2013;7(2):99-105. doi:10.12956/tjpd.2013.2.10
7. Elder DE, Hagan R, Evans SF, et al. Recurrent Wheezing in Very Preterm Infants. Vol 74.;1996.
8. Leps C, Carson C, Quigley MA. Gestational age at birth and wheezing trajectories at 3-11 years. Arch Dis Child. 2018;103(12):1138-1144. doi:10. 1136/archdischild-2017-314541
9. Guilbert T, Krawiec M. Natural history of asthma. Pediatr Clin North Am. 2003;50(3):523-538. doi:10.1016/S0031-3955(03)00044-0
10. Hennessy EM, Bracewell MA, Wood N, et al. Respiratory health in pre-school and school age children following extremely preterm birth. Arch Dis Child. 2008;93(12):1037-1043. doi:10.1136/adc.2008.140830
11. Bisgaard H, Klug B. Lung function measurement in awake young children. Eur Respirat J. 1995;8(12):2067-2075. doi:10.1183/09031936.95.08122067
12. Bridge P, Ranganathan S, McKenzie S, Elizabeth Children Q. Measurement of airway resistance using the interrupter technique in preschool children in the ambulatory setting. Vol 13.; 1999.
13. Demir Özek G, Asilsoy S, Bak M, Maden F, Can D. Reference values for airway resistance measured by the interrupter technique in preschool children. J Dr Behcet Uz Children s Hospital. 2014. doi:10.5222/buchd.2014. 176
14. Kairamkonda VR, Richardson J, Subhedar N, Bridge PD, Shaw NJ. Lung function measurement in prematurely born preschool children with and without chronic lung disease. J Perinatol. 2008;28(3):199-204. doi:10.1038/sj.jp.7211911
15. Vrijlandt EJLE, Boezen HM, Gerritsen J, Stremmelaar EF, Duiverman EJ. Respiratory health in prematurely born preschool children with and without bronchopulmonary dysplasia. J Pediatr. 2007;150(3):256-261. doi: 10.1016/j.jpeds.2006.12.007
Article available in :
Volume 4, Issue 4, 2024
Page : 170-174
https://doi.org/10.51271/KMJ-0166
Article Information
Received : 11 Tem 2024
Accepted : 26 Ağu 2024
Published : 01 Ara 2024
Corresponding Author :

Fayize Maden Bedel: Genetic Diseases Diagnosis Center, Erzurum City Hospital, Erzurum, Turkiye

[email protected]
Citation : Maden Bedel F, Can D, Arslanoğlu S. Investigation of the frequency of wheezing and airway resistance using the interrupter technique in children born premature and over 3 years old. Kastamonu Med J. 2024;4(4):170-174.

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