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Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Case Report
Catatonia and associated psychopathologies in adolescence: case series and a brief review
Catatonia is a severe motor dysregulation syndrome observed in both psychiatric and medical conditions, with potentially fatal outcomes if untreated. This report presents three adolescent cases diagnosed with catatonia, each associated with distinct psychiatric pathologies. Despite varying symptoms, including negativism, mutism, echolalia, and rigidity, all cases responded to benzodiazepine treatment, with one requiring electroconvulsive therapy due to malignant catatonia. This brief review discusses the diagnostic challenges, treatment approaches, and importance of early intervention in catatonia. The comparison of symptoms across cases highlights the role of differential diagnosis in optimizing treatment outcomes for pediatric catatonia.


1. Dhossche DM, Wachtel LE. Catatonia is hidden in plain sight among different pediatric disorders: a review article. Pediatr Neurol. 2010;43(5): 307-315. doi:10.1016/j.pediatrneurol.2010.07.001
2. Carroll BT. Catatonia: a clinician’s guide to diagnosis and treatment. Psychol Med. 2004;34(6):1139-1140. doi:10.1017/S0033291704233207
3. Cohen D, Nicolas JD, Flament MF, et al. Clinical relevance of chronic catatonic schizophrenia in children and adolescents: evidence from a prospective naturalistic study. Schizophr Res. 2005;76(2-3):301-308. doi: 10.1016/j.schres.2005.01.014
4. Thakur A, Jagadheesan K, Dutta S, Sinha VK. Incidence of catatonia in children and adolescents in a paediatric psychiatric clinic. Aust N Z J Psychiatry. 2003;37(2):200-203. doi:10.1046/j.1440-1614.2003.01125.x
5. Cornic F, Consoli A, Tanguy ML, et al. Association of adolescent catatonia with increased mortality and morbidity: evidence from a prospective follow-up study. Schizophr Res. 2009;113(2-3):233-240. doi: 10.1016/j.schres.2009.04.021
6. Ghaziuddin N, Hendriks M, Patel P, Wachtel LE, Dhossche DM. Neuroleptic malignant syndrome/malignant catatonia in child psychiatry: literature review and a case series. J Child Adolesc Psychopharmacol. 2017;27(4):359-365. doi:10.1089/cap.2016.0180
7. American Psychiatric Association, DSM-5 Task Force. Diagnostic and statistical manual of mental disorders: DSM-5™ (5th ed.). American Psychiatric Publishing, Inc. 2013.
8. Bush G, Fink M, Petrides G, Dowling F, Francis A. Catatonia. I. Rating Scale and standardized examination. Acta Psychiatr Scand. 1996;93(2): 129-136. doi:10.1111/j.1600-0447.1996.tb09814.x
9. Karmacharya R, England ML, Ongür D. Delirious mania: clinical features and treatment response. J Affect Disord. 2008;109(3):312-316. doi:10.1016/j.jad.2007.12.001
10. Caroff SN. The neuroleptic malignant syndrome. J Clin Psychiatry. 1980; 41(3):79-83.
11. Smego RA Jr, Durack DT. The neuroleptic malignant syndrome. Arch Intern Med. 1982;142(6):1183-1185.
12. Carroll BT. Kahlbaum’s catatonia revisited. Psychiatry Clin Neurosci. 2001;55(5):431-436. doi:10.1046/j.1440-1819.2001.00887.x
13. Wijemanne S, Jankovic J. Movement disorders in catatonia. J Neurol Neurosurg Psychiatry. 2015;86(8):825-832. doi:10.1136/jnnp-2014-309098
14. Carroll BT, Kirkhart R, Ahuja N, et al. Katatonia: a new conceptual understanding of catatonia and a new rating scale. Psychiatry (Edgmont). 2008;5(12):42-50.
15. Cohen D. Towards a valid nosography and psychopathology of catatonia in children and adolescents. Int Rev Neurobiol. 2006;72:131-147. doi:10. 1016/S0074-7742(05)72008-0
16. Dhossche D, Cohen D, Ghaziuddin N, Wilson C, Wachtel LE. The study of pediatric catatonia supports a home of its own for catatonia in DSM-5. Med Hypotheses. 2010;75(6):558-560. doi:10.1016/j.mehy.2010.07.029
17. Andersson P, Wachtel LE, Lundberg J, et al. Youth with severe mental illness and complex non-somatic motor abnormalities: conflicting conceptualizations and unequal treatment. Npj Ment Health Res. 2022; 1(1):13. doi:10.1038/s44184-022-00013-8
18. Sienaert P, Rooseleer J, De Fruyt J. Measuring catatonia: a systematic review of rating scales. J Affect Disord. 2011;135(1-3):1-9. doi:10.1016/j.jad.2011.02.012
19. Gouzoulis-Mayfrank E, Heekeren K, Neukirch A, et al. Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers. Pharmacopsychiatry. 2005;38(6):301-311. doi:10.1055/s-2005-916185
20. Carroll BT, Goforth HW, Thomas C, et al. Review of adjunctive glutamate antagonist therapy in the treatment of catatonic syndromes. J Neuropsychiatry Clin Neurosci. 2007;19(4):406-412. doi:10.1176/jnp. 2007.19.4.406.
21. Walther S, Strik W. Catatonia. CNS Spectr. 2016;21(4):341-348. doi:10. 1017/S1092852916000274
22. Consoli A, Raffin M, Laurent C, et al. Medical and developmental risk factors of catatonia in children and adolescents: a prospective case-control study. Schizophr Res. 2012;137(1-3):151-158. doi:10.1016/j.schres. 2012.02.012
23. Raffin M, Consoli A, Giannitelli M, et al. Catatonia in children and adolescents: a high rate of genetic conditions. J Am Acad Child Adolesc Psychiatry. 2018;57(7):518-525.e1. doi:10.1016/j.jaac.2018.03.020
24. Byrne S, Walsh C, Hacohen Y, et al. Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome. Neurol Neuroimmunol Neuroinflamm. 2015;2(4):e130. doi:10.1212/NXI.00000 00000000130
25. Ferrafiat V, Raffin M, Freri E, et al. A causality algorithm to guide diagnosis and treatment of catatonia due to autoimmune conditions in children and adolescents. Schizophr Res. 2018;200:68-76. doi:10.1016/j.schres.2017.06.036
26. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12(2): 157-165. doi:10.1016/S1474-4422(12)70310-1
27. Livingston B, Bonner A, Pope J. Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis. Lupus. 2011;20(13):1345-1355. doi:10.1177/0961203311416694
28. Montagna G, Imperiali M, Agazzi P, et al. Hashimoto’s encephalopathy: a rare proteiform disorder. Autoimmun Rev. 2016;15(5):466-476. doi:10. 1016/j.autrev.2016.01.014
29. Schlansky K, Facer B, Tanguturi YC, Cundiff AW, Fuchs DC. Pediatric acute-onset neuropsychiatric syndrome and catatonia: a case report. Psychosomatics. 2020;61(1):86-91. doi:10.1016/j.psym.2019.03.007
30. Swedo SE, Seidlitz J, Kovacevic M, et al. Clinical presentation of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections in research and community settings. J Child Adolesc Psychopharmacol. 2015;25(1):26-30. doi:10.1089/cap.2014.0073
31. Takaoka K, Takata T. Catatonia in childhood and adolescence. Psychiatry Clin Neurosci. 2003;57(2):129-137. doi:10.1046/j.1440-1819.2003.01092.x
32. Cornic F, Consoli A, Cohen D. Catatonia in children and adolescents. Psychiatric Annals. 2007;37:19-26. doi:10.3928/00485713-20070101-05.
33. Lahutte B, Cornic F, Bonnot O, et al. Multidisciplinary approach of organic catatonia in children and adolescents may improve treatment decision making. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(6):1393-1398. doi:10.1016/j.pnpbp.2008.02.015
34. Wing L, Shah A. Catatonia in autistic spectrum disorders. Br J Psychiatry. 2000;176:357-362. doi:10.1192/bjp.176.4.357
35. Wing L, Shah A. A systematic examination of catatonia-like clinical pictures in autism spectrum disorders. Int Rev Neurobiol. 2006;72:21-39. doi:10.1016/S0074-7742(05)72002-X
36. Wachtel L, Commins E, Park M, Rolider N, Stephens R, Reti I. Neuroleptic malignant syndrome and delirious mania as malignant catatonia in autism: prompt relief with electroconvulsive therapy. Acta Psychiatr Scand. 2015;132(4):319-320. doi:10.1111/acps.12441
37. Hawkins JM, Archer KJ, Strakowski SM, Keck PE. Somatic treatment of catatonia. Int J Psychiatry Med. 1995;25(4):345-369. doi:10.2190/X0FF-VU7G-QQP7-L5V7
38. Benarous X, Raffin M, Ferrafiat V, Consoli A, Cohen D. Catatonia in children and adolescents: New perspectives. Schizophr Res. 2018;200:56-67. doi:10.1016/j.schres.2017.07.028
39. Roberto AJ, Pinnaka S, Mohan A, Yoon H, Lapidus KA. Adolescent catatonia successfully treated with Lorazepam and aripiprazole. Case Rep Psychiatry. 2014;2014:309517. doi:10.1155/2014/309517
40. Strawn JR, Delgado SV. Successful treatment of catatonia with aripiprazole in an adolescent with psychosis. J Child Adolesc Psychopharmacol. 2007;17(5):733-735. doi:10.1089/cap.2007.0036
41. Ishitobi M, Kawatani M, Asano M, et al. Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification. Brain Dev. 2014;36(9):823-825. doi:10.1016/j.braindev.2013.12.005
42. Cohen D, Bonnot O, Bodeau N, Consoli A, Laurent C. Adverse effects of second-generation antipsychotics in children and adolescents: a Bayesian meta-analysis. J Clin Psychopharmacol. 2012;32(3):309-316. doi:10.1097/JCP.0b013e3182549259
43. J&auml;ger M, Haack S, Becker T, Frasch K. Schizoaffective disorder-an ongoing challenge for psychiatric nosology. Eur Psychiatry. 2011;26(3): 159-165. doi:10.1016/j.eurpsy.2010.03.010 </ol> <p>
Volume 5, Issue 3, 2025
Page : 208-213
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