A predictive marker for target organ damage in primary hypertension: serum uric acid levels


  • Fatma Akyel
  • Nisbet Yılmaz




Primary hypertension, hyperuricemia, carotid intima media thickness, left ventricular mass index


Background: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima media thickness (CIMT) in primary hypertension patients.

Material and Method: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients were collected from patient files.

Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75±13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032) and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (β±SE: 1.615±1.03, p<0.05) and CIMT (β±SE: 0.251±0.09, p<0.05).

Conclusion: We found serum uric acid levels to be closely related with the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.


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How to Cite

Akyel, F., & Yılmaz, N. (2021). A predictive marker for target organ damage in primary hypertension: serum uric acid levels. Kastamonu Medical Journal, 1(2), 31–36. https://doi.org/10.51271/KMJ-0008

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