Multiorgan dysfunction due to colchicine

Abstract views: 128 / PDF downloads: 67


  • Hatice KARABULUT Kastamonu Training and Research Hospital
  • Özgür ÖNEN Kastamonu Training and Research Hospital
  • Fatma AKYEL Private Nefes Hospital
  • Fatma Mutlu KUKUL GÜVEN Kastamonu Training and Research Hospital



colchicine, toxicity, multiorgan


Colchicine is used in the treatment of many diseases. It should be used very carefully as the treatment dose and toxic dose are very close to each other and may lead to multiorgan failure. Although colchicine toxicity is usually seen in suicidal use, it may also occur when used in therapeutic doses. In this report, we present a case of a 70-year-old patient who used colchicine due to pericardial effusion over two months and died from multiorgan failure, to draw attention to colchicine toxicity due to using it in therapeutic doses.


Iosfina I, s Lan J, Chin C, Werb R, Levin A. Massive colchicine overdose with recovery. Case Rep Nephrol Urol 2012; 2: 20–4.

Adler Y, Charron P, Imazio M, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio- Thoracic Surgery (EACTS). Eur Heart J 2015; 36: 2921.

Erden A, Karagoz H, Gümüscü HH, et al. Colchicine intoxication: a report of two suicide cases. Ther Clin Risk Manag 2013; 9: 505–9.

Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila) 2010; 48: 407-14.

Erdoğan C, Terzi Demisoy E. “Kolsişin ilişkili pansitopeni ve polinöropati”. Kocaeli Tıp Derg 2017; 6: 77-80

Ben-Chetrit E, Levy M. Colchicine: 1998 update. Semin Arthritis Rheum 1998; 28: 48-59.

Dağ E, Türkel Y, Gökçe B. Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği. Turk J Neurol (Türk Noroloji Dergisi) 2013; 19: 69-71.

Putterman C, Ben-Chetrit E, Caraco Y, Levy M. Colchicine toxicity, clinical pharmacology, risk factors, features, and management. Semin Arthritis Rheum 1991; 21: 143-55.

Stapczynski JS, Rothstein RJ, Gaye WA, Niemann JT. Colchicine overdose: Report of two cases and review of the literature. Ann Emerg Med 1981; 10: 364-9.

Altiparmak MR, Pamuk ON, Pamuk GE, Hamuryudan V, Ataman R, Serdengecti K. Colchicine neuromyopathy: a report of six cases. Clin Exp Rheumatol 2002; 20: 13-6.

Mullins M, Cannarozzi AA, Bailey TC, Ranganathan P. Unrecognized fatalities related to colchicine in hospitalized patients. Clin Toxicol 2011;

: 648-52.

Yoon KH. Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor. J Rheumatol 2001; 28: 1199-200.

Cheung HT, Cantarow WD, Sundharadas G. Colchicine and cytochalasin B (CB) effects on random movement, spreading, and adhesion of mouse macrophages. Exp Cell Res 1978; 111




How to Cite

KOÇ, M., KARABULUT, H., ÖNEN, Özgür, AKYEL, F., & KUKUL GÜVEN, F. M. (2022). Multiorgan dysfunction due to colchicine. Kastamonu Medical Journal, 2(2), 54–56.